The project contains eight work packages (WP), of which four are scientific:
WP1 Complementary and scientific training (lead beneficiary UCPH)
Objectives: 1) Initiation, management and coordination of all training activities in NaToxAq, 2) Training of ESRs in methods, theories and models within the scientific framework of the network, 3) Training of complementary skills of ESRs with a relation to science in a broader context.
(All Partners participates) Management and coordination of all training activities in NaToxAq to achieve a well-organized course programme, courses with the best possible lecturers and outcome, and with clear and efficient organisational support for lecturers and participants. Management is carried out by the WP leader in close collaboration
with the course providers. Guidance with PCPs and timely support to ESRs.
WP2 Emerging natural toxins with potential impact on drinking water quality (lead beneficiary UFZ)
Objectives: 1) Integrated methodology involving in silico, analytical and bioanalytical tools for identification and prioritization of natural toxins with potential impact on the water cycle and drinking water quality, 2) Natural toxin fingerprints in surface water and soil leachates along climate gradients in Europe, 3) New toxins from invasive species with potential to enter the water cycle.
(Partner VEOLIA and AB participates) 1) Development of in silico tools for prioritization of natural toxins according to their potential impact on drinking water quality (SU, WBF), 2) Development of non-target screening approaches for natural toxins in surface waters based on LC-HRMS platforms (CSIC, UFZ), 3) Identification of natural toxin fingerprints in soil leachates (UPCH, WBF, UFZ) and surface waters (CSIC, VEOLIA, UFZ, AB) along climate gradients in Europe, 4) Identification of toxicity fingerprints and new toxins from water extracts of invasive species integrating bioanalytical, analytical and in silico tools (UFZ, WBF, MU).
WP3 Emission and distribution of natural toxins in drinking water resources (lead beneficiary CSIC)
Objectives: 1) New analytical methods: target analysis of cyanotoxins, and biosensor based screening methods, 2) Target screening of toxins in lakes of different regions in Europe along climate gradients, 3) Temporal and spatial variations of toxin production and occurrence in Europe, and 3) Significance of natural toxins from crops, non-crop vegetation and aquatic biota.
(Partner UB, USGS and AT participates) 1) HR-MS analytical methods for targeted analysis of natural toxins (CSIC), 2) Targeted screening for natural toxin fingerprints in waters from different regions and climatic zones (UFZ, USGS), 3) Source and distribution of toxins and their transfer to water reservoirs (CSIC, Fera, UB, UCPH, USGS), 4) Spatial and temporal variation in the production and release of natural toxins from different land uses (MUC, AT, UCPH, WBF), and 5) Identification of risk factors (UCPH, MUC, UFZ, CSIC).
WP4 Fate and Transport of natural toxins in aquatic and terrestrial environments (lead beneficiary WBF)
Objectives 1) Determination of physical-chemical properties of natural toxins, 2) Determination of persistence (dissipation rates) of natural toxins as affected by biotic and abiotic processes, 3) Determination of natural toxins’ fate and behaviour in real environmental systems, with particular focus on leaching and modelling.
(Partner ETH, EAWAG, VCS, SGS and UCPH participates) 1) OECD guideline based experimental systems for determination of physical-chemical properties of natural toxins (WBF, UCPH, SU), 2) Rates of hydrolysis, photolysis and enzymatic transformation of natural toxins, formation of metabolites, and linking chemical transformation to functional changes (EAWAG, UCPH), 3) Field studies to measure and model the emission, transfer ratios and leaching of natural toxins into drinking water supply reservoirs (UCPH, WBF, VCS, SGS)
WP5 Safe Water Supply (lead beneficiary FERA)
Objectives: 1) Quantify efficacy of water treatment technologies to remove natural toxins from surface water including development and testing of non-thermal plasma processes, 2) Determine natural toxin stability in aquifers, 3) Quantify efficacy of different water treatment technologies to remove toxins for groundwater including development and testing of facilitated hydrolysis, 4) Assess human health risks associated with exposure via raw water and drinking water, and 5) Develop predictive model to support risk mitigation.
(Partners VEOLIA, UY, YW, VCS, LIPS, SGS and AB participate) 1) Select toxins found in surface water reservoirs (WP2-4) and determine, experimentally, toxin removal by mi- crobial dissipation, advanced oxidation and non-thermal plasma technologies (MU, VEOLIA, LIPS, UCPH, MUC, UY, YW, SGS, AB), 2) Select toxins likely to be found in groundwater and determine, experimentally, toxin removal/dissipation by sand filters, activated carbon, ozonation and acid/base buffering (HOFOR, UCPH, MUC, VEOLIA, UCPH, VCS, SGS, AB), 3) Cell assays to determine mechanisms of toxicity for mainly cyanobacterial toxins and estimation of human health risks (MU, Fera), 4) Development of a model to predict toxin concentrations in raw water as a function of land use, catchment properties, and climate (Fera, UY, UCPH), and 5) Assessment of the impact of external drives on toxin production/fate via land use change and catchment mitigation measures to reduce exposure risk (Fera, UY, HOFOR, YW).
WP6 Dissemination and Outreach (lead beneficiary UCPH)
Objectives: 1) Scientific publication of results in journals with high impact factors and with high global accessibilities and presentation of results at scientific conferences, 2) Web-site with information portal directed towards stake holders, students and citizens including overview and research updates, 3) Supply data to European databases of emerging contaminants and health risks, and 4) Outreach activities to land owners, water suppliers, food industry, environmental consultants, public regulatory and risk assessment agencies and the EU.
(All Partners participate) 1) Ensure high-quality scientific publication (at least 3 papers per ESR), stimulate multidisciplinary papers across WPs, and at final stages publish reviews and book chapters; 1/3 of papers in openaccess journals, 2) Presentations (preferably oral) at scientific conferences (at least 2 per ESR), 2) Webpage with an internal site for communication in the network including webinar facility, and an external part where each WP contribute to state-of-the-art info portal including short videos, lectures and learning tools, 3) Input of data on natural toxin properties, health attributes, occurrence and distribution to European databases/networks (NORMAN), 4) Outreach via stakeholder seminars, popular science journals or other (incl. social) media (at least 1 per ESR), science festivals, newsletters and merchandise/kits (e.g. analytical and cleaning kits for natural toxins).
WP7 Project management (lead beneficiary UCPH)
Objectives: 1) Administrative head responsible for daily administration assisted by the Project Manager; interaction with partners, 2) Planning and implementation of the training programme in collaboration with the Supervisory Board and with inputs from the Advisory Board, 3) Planning, facilitation and quality assurance of dissemination activities (WP6).
(All Partners participate) The Project Coordinator is responsible for smooth and efficient initiation, financial management and management and coordination of all major activities paying attention to transparency, timing and participatory approaches. The Project Manager assists with all office matters. The Supervisory Board is the key instrument for the Project Coordinator and partners for collaboration and sharing ideas and experiences.
WP8 Ethics requirements (lead beneficiary UCPH)
Objectives: The objective is to ensure compliance with the 'ethics requirements' set out in this work package. This work package sets out the 'ethics requirements' that the project must comply with.